The Bioclave 28L features an increased chamber size with a diameter of 32cm. With this larger internal chamber, the BioClave 28 is capable of sterilizing 1 and 2 liters flasks (and bottles).

Despite the increased chamber size, the unit is still relatively compact, suitable for benchtop use. Operation is fully automatic, meaning all segments of operation (fill, sterilize, exhaust and dry) commence and run to completion by simply pressing "Start''. An optional thermal mini-printer is also available for providing a record of sterilization parameters. In addition, a built in USB port allows for transfer of these parameters to a computer for printing or storage of cycle data.

All BioClaves offer three cycle options (standard programs), which are preset for the sterilization of liquids, wrapped instruments or unwrapped instruments/plasticware. A"Dry Only" option is also available for additional drying time to be added to the end of a cycle. For special applications, requiring variations in cycle parameters, the cycle times are fully adjustable.